Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 16/20 | 0.41 |
| ▸ | RBP1 | P09455 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
| ▸ | FEN1 | P39748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20007310 | 0.88 | TRPV4 (0.49) | TRPV4TRPM8CYP3A4KCNH2 | |
| SCHEMBL23613990 | 0.83 | TRPV4 (0.41) | TRPV4RBP1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL20007693 | 0.83 | TRPV4 (0.41) | TRPV4RBP1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL20007244 | 0.79 | TRPV4 (0.46) | TRPV4 | |
| SCHEMBL20007647 | 0.73 | RBP1 (0.39) | RBP1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL20007441 | 0.70 | POLB (0.56) | TRPV4ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL23613847 | 0.70 | TRPV4 (0.57) | TRPV4TRPM8 | |
| SCHEMBL23614037 | 0.69 | TRPV4 (0.38) | TRPV4ALDH1A1SMN1; SMN2CYP3A4KCNH2 | |
| SCHEMBL20007703 | 0.68 | TRPV4 (0.43) | TRPV4RBP1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL23614048 | 0.67 | TRPV4 (0.40) | TRPV4TRPM8ALDH1A1SMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055524-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |