Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 3/20 | 0.46 |
| ▸ | MET | P08581 | 6/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 9/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | FPR3 | P25089 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | GPR183 | P32249 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14280359 | 0.74 | HTR6 (0.48) | HTR7METHTR6HTR2CCYP3A4 | |
| SCHEMBL1422419 | 0.71 | DYRK1A (0.53) | HTR7METDYRK1AHTR6HTR2C | |
| SCHEMBL13599036 | 0.70 | HTR7 (0.45) | HTR7METHTR6HTR2CCYP3A4 | |
| SCHEMBL344080 | 0.69 | MET (0.52) | HTR7METDYRK1AHTR6HTR2C | |
| SCHEMBL14468673 | 0.69 | DYRK1A (0.50) | HTR7METDYRK1AHTR6HTR2C | |
| SCHEMBL1743494 | 0.68 | MET (0.51) | HTR7METDYRK1AHTR6HTR2C | |
| SCHEMBL1617632 | 0.67 | HDAC3 (0.52) | HTR7METCCKBRBCL2BCL2L1 | |
| SCHEMBL3935685 | 0.67 | MET (0.46) | HTR7METHTR6HTR2CCYP3A4 | |
| SCHEMBL23613995 | 0.67 | TRPV4 (0.42) | — | |
| SCHEMBL23613997 | 0.67 | TRPV4 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055524-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |