Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 6/20 | 0.50 |
| ▸ | RIN1 | Q13671 | 6/20 | 0.50 |
| ▸ | NR2F2 | P24468 | 5/20 | 0.45 |
| ▸ | GALR3 | O60755 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | NAE1 | Q13564 | 3/20 | 0.42 |
| ▸ | UBA3 | Q8TBC4 | 3/20 | 0.42 |
| ▸ | UBA6 | A0AVT1 | 1/20 | 0.42 |
| ▸ | ATG7 | O95352 | 1/20 | 0.42 |
| ▸ | UBA7 | P41226 | 1/20 | 0.42 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12566819 | 0.86 | NPC1 (0.58) | NR2F2NPC1RAB9ASMN1; SMN2ADORA3 | |
| SCHEMBL1796279 | 0.83 | UBA6 (0.60) | NAE1UBA3UBA6ATG7UBA7 | |
| SCHEMBL12567124 | 0.80 | ABL1 (0.49) | ABL1RIN1NR2F2NPC1RAB9A | |
| SCHEMBL12652607 | 0.78 | NR2F2 (0.54) | NR2F2NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL12652414 | 0.78 | UBA6 (0.47) | ABL1RIN1NR2F2GALR3NAE1 | |
| SCHEMBL12567198 | 0.78 | ATG7 (0.46) | NPC1RAB9ASMN1; SMN2ALDH1A1NAE1 | |
| SCHEMBL18630490 | 0.78 | P2RY12 (0.53) | NAE1UBA3UBA6ATG7UBA7 | |
| SCHEMBL12566837 | 0.77 | CCNA2 (0.43) | NPC1RAB9ASMN1; SMN2NAE1UBA3 | |
| SCHEMBL12566427 | 0.76 | DNPH1 (0.47) | ABL1RIN1NR2F2GALR3ALDH1A1 | |
| SCHEMBL12567224 | 0.76 | ADORA3 (0.44) | NPC1RAB9ASMN1; SMN2PAX8NAE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180086785-A1 | SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES | MILLENNIUM PHARMACEUTICALS, INC. | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086785-A1 | SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES | TYMP, TYMS, PPA1 | ABL1 2724/4885RIN1 2025/4885NR2F2 2928/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.