Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008363 | 0.77 | MAPT (0.37) | RAB9ASMN1; SMN2ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL20009063 | 0.76 | NPC1 (0.39) | RAB9ASMN1; SMN2ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL12813152 | 0.70 | KMT2A (0.58) | RAB9ASMN1; SMN2ALDH1A1L3MBTL1GAA | |
| SCHEMBL20008169 | 0.69 | PABPC1 (0.34) | — | |
| SCHEMBL19529299 | 0.68 | SMN1; SMN2 (0.41) | RAB9ASMN1; SMN2ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL20008379 | 0.68 | — | — | |
| SCHEMBL20008272 | 0.67 | TP53 (0.40) | RAB9ASMN1; SMN2ALDH1A1MAPTHPGD | |
| SCHEMBL20008164 | 0.66 | MAPT (0.32) | RAB9ASMN1; SMN2MAPTL3MBTL1NPC1 | |
| SCHEMBL13069540 | 0.64 | ALDH1A1 (0.51) | RAB9ASMN1; SMN2ALDH1A1L3MBTL1AKR1C3 | |
| SCHEMBL20008429 | 0.63 | TP53 (0.40) | RAB9ASMN1; SMN2ALDH1A1MAPTCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |