Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TGM2 | P21980 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008363 | 0.80 | MAPT (0.37) | NPC1RAB9AHTTL3MBTL1SMN1; SMN2 | |
| SCHEMBL20009063 | 0.79 | NPC1 (0.39) | NPC1RAB9AHTTL3MBTL1SMN1; SMN2 | |
| SCHEMBL20008487 | 0.75 | NPC1 (0.36) | NPC1RAB9AHTTL3MBTL1SMN1; SMN2 | |
| SCHEMBL20008164 | 0.74 | MAPT (0.32) | NPC1RAB9AHTTL3MBTL1SMN1; SMN2 | |
| SCHEMBL20008308 | 0.71 | NPC1 (0.36) | NPC1RAB9AHTTL3MBTL1SMN1; SMN2 | |
| SCHEMBL20009463 | 0.69 | NPC1 (0.32) | NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL20008233 | 0.68 | RAB9A (0.39) | NPC1RAB9AHTTL3MBTL1SMN1; SMN2 | |
| SCHEMBL20008169 | 0.67 | PABPC1 (0.34) | — | |
| SCHEMBL20008186 | 0.64 | — | — | |
| SCHEMBL23019251 | 0.62 | TGM2 (0.33) | NPC1RAB9AL3MBTL1TGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |