Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008452 | 0.82 | GALR2 (0.44) | SMN1; SMN2CRHBPCRHR2L3MBTL1KDM4E | |
| SCHEMBL20008237 | 0.78 | HRH4 (0.47) | HRH4RAF1BRAF | |
| SCHEMBL20008538 | 0.78 | DRD2 (0.49) | SMN1; SMN2RAF1L3MBTL1KDM4EGAA | |
| SCHEMBL20009412 | 0.77 | RAF1 (0.40) | RAF1BRAFL3MBTL1KDM4EGAA | |
| SCHEMBL19529392 | 0.77 | RAF1 (0.40) | SMN1; SMN2RAF1BRAFL3MBTL1KDM4E | |
| SCHEMBL20008460 | 0.75 | RAF1 (0.41) | SMN1; SMN2RAF1BRAFL3MBTL1KDM4E | |
| SCHEMBL28957811 | 0.74 | HRH4 (0.58) | SMN1; SMN2CRHBPCRHR2HRH4KDM4E | |
| SCHEMBL20009430 | 0.73 | RAF1 (0.49) | RAF1BRAFL3MBTL1KDM4EGAA | |
| SCHEMBL20010376 | 0.72 | AR (0.53) | SMN1; SMN2CRHBPCRHR2RAF1BRAF | |
| SCHEMBL1442527 | 0.72 | CNR2 (0.43) | SMN1; SMN2HRH4L3MBTL1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |