Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.31 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3674435 | 0.85 | TP53 (0.45) | TP53TDP1ALDH1A1TSHRPLAU | |
| SCHEMBL29375309 | 0.84 | TP53 (0.52) | TP53TDP1ALDH1A1TSHRFAAH | |
| SCHEMBL595016 | 0.84 | TP53 (0.52) | TP53TDP1ALDH1A1TSHRFAAH | |
| SCHEMBL1645656 | 0.82 | TP53 (0.50) | TP53TDP1ALDH1A1TSHRPLAU | |
| SCHEMBL29619562 | 0.82 | TP53 (0.50) | TP53TDP1ALDH1A1TSHRPLAU | |
| SCHEMBL1646925 | 0.80 | TP53 (0.48) | TP53TDP1ALDH1A1TSHRFAAH | |
| SCHEMBL29619625 | 0.80 | TP53 (0.48) | TP53TDP1ALDH1A1TSHRFAAH | |
| SCHEMBL595251 | 0.79 | TP53 (0.47) | TP53TDP1ALDH1A1TSHRFAAH | |
| SCHEMBL10616284 | 0.79 | ALDH1A1 (0.52) | TP53TDP1ALDH1A1TSHRFAAH | |
| SCHEMBL3679531 | 0.78 | TDP1 (0.42) | TP53TDP1ALDH1A1TSHRFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |