SCHEMBL20008490

SCHEMBL20008490

C=N/C=C(\C=C/C1CCCCC1)c1cc(NC)cnc1C

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PLAU P00749 1/20 0.32
PLAT P00750 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20008799 0.82
SCHEMBL20008349 0.81 LDLR (0.32)
SCHEMBL20008372 0.81 OPRK1 (0.31)
SCHEMBL20008433 0.78 PRMT5 (0.30)
SCHEMBL22561897 0.72
SCHEMBL20008589 0.69 GRIN1 (0.34)
SCHEMBL20008807 0.69 LDLR (0.31)
SCHEMBL20008220 0.65 RRM2 (0.31)
SCHEMBL20009507 0.64 MAPT (0.33)
SCHEMBL20008179 0.64 MAPT (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3299367-A1 BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS Novartis AG (CH) 2018-03-28 EP disclosed