Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDLR | P01130 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008349 | 0.87 | LDLR (0.32) | LDLRNPC1RAB9AGRIN1GRIN2B | |
| SCHEMBL20008589 | 0.70 | GRIN1 (0.34) | GRIN1GRIN2B | |
| SCHEMBL20008490 | 0.69 | PLAU (0.32) | — | |
| SCHEMBL20009403 | 0.64 | — | — | |
| SCHEMBL20008372 | 0.63 | OPRK1 (0.31) | — | |
| SCHEMBL20009063 | 0.62 | NPC1 (0.39) | NPC1RAB9A | |
| SCHEMBL20009577 | 0.61 | — | — | |
| SCHEMBL20008186 | 0.61 | — | — | |
| SCHEMBL20008531 | 0.61 | — | — | |
| SCHEMBL18648536 | 0.60 | APP (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |