SCHEMBL20009248

SCHEMBL20009248

C=C(Nc1ccc(C)c(C(=N)/C=C\C)c1)C(=C/N(C)CC)/C=C(\C=O)C(F)(F)F

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.31
BTK Q06187 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20009217 0.62 RAF1 (0.39) BTK
SCHEMBL25732408 0.57 CYP2D6 (0.40) ALDH1A1
SCHEMBL20008773 0.55 CASP1 (0.42) ALDH1A1
SCHEMBL21983387 0.53 MEN1 (0.38) ALDH1A1
SCHEMBL22809131 0.53 TRPA1 (0.31)
SCHEMBL13693069 0.51 ADRB2 (0.53) ALDH1A1
SCHEMBL22239440 0.50
SCHEMBL16091394 0.50
SCHEMBL20008531 0.49
SCHEMBL24316662 0.48 ALDH1A1 (0.40) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3299367-A1 BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS Novartis AG (CH) 2018-03-28 EP disclosed