Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.40 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.40 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.40 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20009709 | 0.72 | BRAF (0.39) | BRAFNR1I2SMARCA2SMARCA4PBRM1 | |
| SCHEMBL16727174 | 0.69 | SLC18A3 (0.55) | MAPTALDH1A1TSHRMCOLN3MEN1 | |
| SCHEMBL3162979 | 0.68 | SLC18A3 (0.57) | MAPTALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL19051396 | 0.68 | AR (0.78) | ARMEN1KMT2ATP53TLR8 | |
| SCHEMBL20008359 | 0.68 | CNR2 (0.42) | ARMAPTALDH1A1MCOLN3MEN1 | |
| SCHEMBL15871966 | 0.67 | MAPT (0.49) | MAPTALDH1A1TSHRMCOLN3MEN1 | |
| SCHEMBL13326993 | 0.67 | MEN1 (0.47) | MAPTALDH1A1TSHRMCOLN3MEN1 | |
| SCHEMBL4885809 | 0.66 | MAPT (0.68) | MAPTALDH1A1MCOLN3MEN1KMT2A | |
| SCHEMBL20008248 | 0.66 | KMO (0.37) | BRAFNR1I2SMARCA2SMARCA4PBRM1 | |
| SCHEMBL20008296 | 0.66 | SMARCA2 (0.40) | BRAFNR1I2SMARCA2SMARCA4PBRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |