Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.39 |
| ▸ | RAF1 | P04049 | 16/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.34 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.34 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008238 | 0.76 | KMO (0.37) | BRAFRAF1 | |
| SCHEMBL20009415 | 0.75 | RAF1 (0.37) | BRAFRAF1 | |
| SCHEMBL20008778 | 0.74 | RAF1 (0.37) | BRAFRAF1 | |
| SCHEMBL20009643 | 0.72 | BRAF (0.43) | BRAFRAF1NR1I2SMARCA2SMARCA4 | |
| SCHEMBL20008213 | 0.72 | RAF1 (0.38) | BRAFRAF1NPY5R | |
| SCHEMBL20008197 | 0.69 | RAF1 (0.39) | BRAFRAF1 | |
| SCHEMBL20008496 | 0.69 | RAF1 (0.37) | BRAFRAF1 | |
| SCHEMBL20008341 | 0.68 | RAF1 (0.38) | BRAFRAF1 | |
| SCHEMBL20009443 | 0.67 | RAF1 (0.37) | BRAFRAF1 | |
| SCHEMBL20008313 | 0.65 | ROCK2 (0.41) | BRAFRAF1NR1I2SMARCA2SMARCA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |