Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 8/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2006974 | 0.93 | LMNA (0.38) | MAPTGRM5ALOX5APSMN1; SMN2MEN1 | |
| SCHEMBL2004149 | 0.92 | GRM5 (0.41) | MAPTTP53GRM5NPC1PKM | |
| SCHEMBL2002250 | 0.91 | PLA2G2A (0.43) | PLA2G2AMAPTACHEALOX5APPKM | |
| SCHEMBL2000835 | 0.90 | PLA2G2A (0.38) | PLA2G2AMAPTTP53GRM5ACHE | |
| SCHEMBL2002620 | 0.90 | PLA2G2A (0.37) | PLA2G2AMAPTTP53PTGDR2ALOX5AP | |
| SCHEMBL2003537 | 0.90 | GRM5 (0.38) | MAPTGRM5PTGDR2NPC1SMN1; SMN2 | |
| SCHEMBL2007043 | 0.89 | PLA2G2A (0.42) | PLA2G2AMAPTTP53ALOX5APPKM | |
| SCHEMBL2005836 | 0.89 | L3MBTL1 (0.41) | MAPTGRM5NPC1PKMRAB9A | |
| SCHEMBL2005827 | 0.89 | LMNA (0.43) | MAPTTP53GRM5NPC1PKM | |
| SCHEMBL2001691 | 0.88 | NPC1 (0.41) | PLA2G2AMAPTTP53GRM5PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |