Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 5/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | F2RL3 | Q96RI0 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | GPR39 | O43194 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2003268 | 0.94 | ALOX5AP (0.36) | TP53MAPTALOX5APF2RL3CYP2C9 | |
| SCHEMBL2004941 | 0.93 | GRM5 (0.38) | TP53MAPTCYP2D6CYP2C9CYP1A2 | |
| SCHEMBL2002685 | 0.91 | PLA2G2A (0.37) | PLA2G2ATP53MAPTALOX5APPTGS2 | |
| SCHEMBL2006492 | 0.91 | GRM5 (0.35) | MAPTALOX5APCYP2D6CYP2C9CYP1A2 | |
| SCHEMBL2001297 | 0.90 | PLA2G2A (0.38) | PLA2G2ATP53MAPTALOX5APACHE | |
| SCHEMBL2002391 | 0.90 | L3MBTL1 (0.39) | MAPTALOX5APCYP2D6CYP2C9CYP1A2 | |
| SCHEMBL2002093 | 0.90 | LMNA (0.40) | TP53MAPTCYP2D6CYP2C9CYP1A2 | |
| SCHEMBL4564522 | 0.89 | NPC1 (0.38) | PLA2G2ATP53MAPTALOX5APPTGS2 | |
| SCHEMBL2003372 | 0.88 | PLA2G2A (0.38) | PLA2G2AMAPTALOX5APPTGS2F2RL3 | |
| SCHEMBL2001214 | 0.88 | PLA2G2A (0.38) | PLA2G2ATP53MAPTPTGS2F2RL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |