Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 5/20 | 0.36 |
| ▸ | FAAH | O00519 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | GPR39 | O43194 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1999092 | 0.96 | L3MBTL1 (0.42) | GRM5MEN1KMT2ANPSR1CYP1A2 | |
| SCHEMBL2004149 | 0.94 | GRM5 (0.41) | GRM5MEN1KMT2ANPSR1CYP1A2 | |
| SCHEMBL2005836 | 0.91 | L3MBTL1 (0.41) | GRM5MEN1KMT2ANPSR1CYP1A2 | |
| SCHEMBL2006918 | 0.91 | FAAH (0.44) | MEN1KMT2AFAAHCES1MAPT | |
| SCHEMBL2005827 | 0.91 | LMNA (0.43) | GRM5MEN1KMT2ANPSR1CYP1A2 | |
| SCHEMBL2006492 | 0.90 | GRM5 (0.35) | GRM5MEN1KMT2ANPSR1CYP1A2 | |
| SCHEMBL2001297 | 0.90 | PLA2G2A (0.38) | GRM5MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL2001504 | 0.90 | FAAH (0.35) | MEN1KMT2ANPSR1CYP1A2CYP2D6 | |
| SCHEMBL2006974 | 0.89 | LMNA (0.38) | GRM5MEN1KMT2ANPSR1CYP1A2 | |
| SCHEMBL2004165 | 0.88 | LMNA (0.38) | KMT2ANPSR1CYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |