Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD1 | P21728 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | DRD5 | P21918 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 3/20 | 0.34 |
| ▸ | HSD17B3 | P37058 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20123632 | 0.83 | MEN1 (0.37) | KMT2AMEN1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL20123824 | 0.78 | MEN1 (0.34) | KMT2AMEN1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL20123727 | 0.78 | ACHE (0.35) | KMT2AMEN1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL20014966 | 0.77 | NOTUM (0.40) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL20015248 | 0.77 | HSD17B3 (0.39) | KMT2AMEN1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL20015054 | 0.74 | TRPA1 (0.40) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL20123682 | 0.74 | ALDH1A1 (0.37) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL13113542 | 0.73 | MEN1 (0.66) | KMT2AMEN1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL19334832 | 0.72 | ALDH1A1 (0.37) | KMT2AMEN1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL11878033 | 0.72 | ACHE (0.50) | KMT2AMEN1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2620436-B1 | SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG | SHIONOGI & CO (JP) | 2018-05-09 | — | — | EP | disclosed |
| EP-2444400-B1 | SUBSTITUTED POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE | SHIONOGI & CO (JP) | 2018-03-28 | — | — | EP | disclosed |