Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2009494 | 0.95 | FAAH (0.37) | ALDH1A1LMNAMAPTALOX12FAAH | |
| SCHEMBL2007718 | 0.92 | L3MBTL1 (0.43) | L3MBTL1ALDH1A1LMNAMAPTALOX12 | |
| SCHEMBL2000766 | 0.91 | FAAH (0.36) | L3MBTL1ALDH1A1LMNAMAPTALOX12 | |
| SCHEMBL2003317 | 0.91 | L3MBTL1 (0.38) | L3MBTL1ALDH1A1LMNAMAPTALOX12 | |
| SCHEMBL2005968 | 0.91 | LMNA (0.41) | ALDH1A1LMNAMAPTALOX12FAAH | |
| SCHEMBL2004090 | 0.90 | PTGES2 (0.40) | ALDH1A1LMNAMAPTALOX12FAAH | |
| SCHEMBL2008663 | 0.90 | L3MBTL1 (0.36) | L3MBTL1ALDH1A1LMNAMAPTALOX12 | |
| SCHEMBL2003366 | 0.89 | TP53 (0.39) | ALDH1A1MAPTFAAHKDM4EPOLB | |
| SCHEMBL2003027 | 0.88 | POLB (0.37) | ALDH1A1LMNAMAPTALOX12FAAH | |
| SCHEMBL2002487 | 0.86 | LMNA (0.40) | L3MBTL1ALDH1A1LMNAMAPTALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |