Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2009494 | 0.94 | FAAH (0.37) | FAAHLMNAALDH1A1MAPTALOX12 | |
| SCHEMBL2005357 | 0.92 | LMNA (0.38) | FAAHLMNAALDH1A1MAPTALOX12 | |
| SCHEMBL2001640 | 0.91 | L3MBTL1 (0.39) | FAAHLMNAALDH1A1MAPTALOX12 | |
| SCHEMBL2006660 | 0.91 | CYP2C9 (0.37) | FAAHLMNAALDH1A1MAPTALOX12 | |
| SCHEMBL2005968 | 0.90 | LMNA (0.41) | FAAHLMNAALDH1A1MAPTALOX12 | |
| SCHEMBL2005285 | 0.90 | PTGES2 (0.43) | FAAHALDH1A1MAPTALOX12KDM4E | |
| SCHEMBL2004824 | 0.90 | PTGES2 (0.36) | FAAHLMNAALDH1A1MAPTALOX12 | |
| SCHEMBL2003366 | 0.90 | TP53 (0.39) | FAAHALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL2003027 | 0.89 | POLB (0.37) | FAAHLMNAALDH1A1MAPTALOX12 | |
| SCHEMBL2006623 | 0.87 | POLB (0.38) | FAAHLMNAALDH1A1MAPTALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |