SCHEMBL20021588

SCHEMBL20021588

CCN1CCCc2cc(C(=O)c3ccccc3C(=O)O)c(O)cc21

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.49
GAA P10253 4/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
MAPT P10636 2/20 0.49
CASP1 P29466 2/20 0.49
HTT P42858 2/20 0.49
ALOX15 P16050 1/20 0.49
TSHR P16473 1/20 0.49
MEN1 O00255 3/20 0.44
KMT2A Q03164 3/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
KDM4E B2RXH2 2/20 0.41
POLB P06746 1/20 0.41
ALPL P05186 1/20 0.41
ALPG P10696 1/20 0.41
ACHE P22303 1/20 0.39
PDK1 Q15118 2/20 0.38
PDK2 Q15119 2/20 0.38
PDK3 Q15120 2/20 0.38
PDK4 Q16654 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29647869 1.00 ALDH1A1 (0.49) ALDH1A1GAASMN1; SMN2MAPTCASP1
SCHEMBL6858751 0.82 ALDH1A1 (0.53) ALDH1A1GAASMN1; SMN2MAPTCASP1
SCHEMBL22692579 0.80 ALDH1A1 (0.43) ALDH1A1GAASMN1; SMN2MAPTCASP1
SCHEMBL7096495 0.78 ALDH1A1 (0.45) ALDH1A1GAASMN1; SMN2MAPTCASP1
SCHEMBL22140444 0.78 KMT2A (0.47) ALDH1A1GAASMN1; SMN2MAPTCASP1
SCHEMBL20178669 0.72 ACHE (0.53) ALDH1A1GAAMAPTCASP1HTT
SCHEMBL20178649 0.72 ALDH1A1 (0.52) ALDH1A1GAASMN1; SMN2MAPTCASP1
SCHEMBL6645348 0.71 HRH3 (0.47) ALDH1A1GAASMN1; SMN2MAPTCASP1
SCHEMBL6850945 0.70 HDAC1 (0.44) ALDH1A1GAAMAPTCASP1HTT
SCHEMBL7111918 0.70 ALDH1A1 (0.38) ALDH1A1GAASMN1; SMN2MAPTCASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3974425-B1 NEW FLUORESCENT DYES AND THEIR USES AS BIOMARKERS ILLUMINA CAMBRIDGE LTD (GB) 2024-07-10 EP disclosed
EP-3974425-B1 NEW FLUORESCENT DYES AND THEIR USES AS BIOMARKERS ILLUMINA CAMBRIDGE LTD (GB) 2024-07-10 EP disclosed
US-11370920-B2 Fluorescent dyes and their uses as biomarkers ILLUMINA CAMBRIDGE LIMITED (GB) 2022-06-28 US disclosed
US-11370920-B2 Fluorescent dyes and their uses as biomarkers ILLUMINA CAMBRIDGE LIMITED (GB) 2022-06-28 US disclosed
CN-109476654-B Novel fluorescent dyes and their use as biomarkers 伊鲁米纳剑桥有限公司 2022-06-10 CN disclosed
EP-3974425-A1 NEW FLUORESCENT DYES AND THEIR USES AS BIOMARKERS Illumina Cambridge Limited (GB) 2022-03-30 EP disclosed
EP-3519410-B1 NEW FLUORESCENT DYES AND THEIR USES AS BIOMARKERS ILLUMINA CAMBRIDGE LTD (GB) 2022-03-30 EP disclosed
EP-3974425-A1 NEW FLUORESCENT DYES AND THEIR USES AS BIOMARKERS Illumina Cambridge Limited (GB) 2022-03-30 EP disclosed
EP-3519410-B1 NEW FLUORESCENT DYES AND THEIR USES AS BIOMARKERS ILLUMINA CAMBRIDGE LTD (GB) 2022-03-30 EP disclosed
US-20210071005-A1 FLUORESCENT DYES AND THEIR USES AS BIOMARKERS ILLUMINA CAMBRIDGE LIMITED (GB) 2021-03-11 US disclosed
US-20210071005-A1 FLUORESCENT DYES AND THEIR USES AS BIOMARKERS ILLUMINA CAMBRIDGE LIMITED (GB) 2021-03-11 US disclosed
US-10844225-B2 Fluorescent dyes and their uses as biomarkers ILLUMINA CAMBRIDGE LIMITED (GB) 2020-11-24 US disclosed
US-10385214-B2 Fluorescent dyes and their uses as biomarkers ILLUMINA CAMBRIDGE LIMITED (GB) 2019-08-20 US disclosed
WO-2018060482-A1 NEW FLUORESCENT DYES AND THEIR USES AS BIOMARKERS ILLUMINA CAMBRIDGE LIMITED (GB) 2018-04-05 WO disclosed
US-20180094140-A1 FLUORESCENT DYES AND THEIR USES AS BIOMARKERS ILLUMINA CAMBRIDGE LIMITED (GB) 2018-04-05 US disclosed
US-20180094140-A1 FLUORESCENT DYES AND THEIR USES AS BIOMARKERS ILLUMINA CAMBRIDGE LIMITED (GB) 2018-04-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10844225-B2 Fluorescent dyes and their uses as biomarkers FBL, HNRNPF, EWSR1 ALDH1A1 895/4885GAA 1533/4885SMN1; SMN2 2898/4885
US-11370920-B2 Fluorescent dyes and their uses as biomarkers FBL, HNRNPF, EWSR1 ALDH1A1 895/4885GAA 1533/4885SMN1; SMN2 2898/4885
US-10385214-B2 Fluorescent dyes and their uses as biomarkers FBL, EWSR1, HNRNPF ALDH1A1 1051/4885GAA 1463/4885SMN1; SMN2 3182/4885
US-20210071005-A1 FLUORESCENT DYES AND THEIR USES AS BIOMARKERS FBL, HNRNPF, EWSR1 ALDH1A1 895/4885GAA 1533/4885SMN1; SMN2 2898/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.