Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 8/20 | 0.50 |
| ▸ | DRD2 | P14416 | 8/20 | 0.50 |
| ▸ | HTR7 | P34969 | 7/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.50 |
| ▸ | HTR2A | P28223 | 7/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20023020 | 0.82 | L3MBTL1 (0.70) | RAB9ASMN1; SMN2HPGDL3MBTL1MAPK1 | |
| SCHEMBL20029262 | 0.81 | CSNK1D (0.64) | NPC1RAB9ASMN1; SMN2MAPK1MAPT | |
| SCHEMBL1950317 | 0.79 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL7639974 | 0.77 | MAPT (0.72) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL20023040 | 0.76 | TDP1 (0.56) | NPC1RAB9AL3MBTL1MAPK1SLC6A2 | |
| SCHEMBL27451031 | 0.75 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL31549929 | 0.75 | HTT (0.59) | SMN1; SMN2L3MBTL1MAPK1SLC6A2MAPT | |
| SCHEMBL19043117 | 0.74 | DRD2 (0.61) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL5516342 | 0.74 | DRD2 (0.55) | NPC1RAB9ASMN1; SMN2HPGDHTR1A | |
| SCHEMBL5973802 | 0.74 | RAB9A (1.00) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594563-B1 | 2-acylaminopropanol-type glucosylceramide synthase inhibitors | GENZYME CORP (US) | 2018-07-18 | — | — | EP | disclosed |
| US-20180093981-A1 | 2-Acylaminopropoanol-Type Glucosylceramide Synthase Inhibitors | GENZYME CORPORATION | 2018-04-05 | — | — | US | disclosed |
| US-20180093981-A1 | 2-Acylaminopropoanol-Type Glucosylceramide Synthase Inhibitors | GENZYME CORPORATION | 2018-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180093981-A1 | 2-Acylaminopropoanol-Type Glucosylceramide Synthase Inhibitors | ASAH2, GBA1, GAA | NPC1 254/4885RAB9A 2280/4885SMN1; SMN2 964/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.