Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.55 |
| ▸ | HTR7 | P34969 | 9/20 | 0.55 |
| ▸ | HTR1A | P08908 | 8/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 9/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.51 |
| ▸ | HRH1 | P35367 | 2/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049744 | 0.92 | NPC1 (0.56) | DRD2HTR7HTR1ASLC6A4NPC1 | |
| SCHEMBL28172146 | 0.80 | DRD2 (0.62) | DRD2HTR7HTR1ASLC6A4NPC1 | |
| Bromide SCHEMBL28956727 | 0.80 | DRD2 (0.62) | DRD2HTR7HTR1ASLC6A4NPC1 | |
| SCHEMBL19043117 | 0.79 | DRD2 (0.61) | DRD2HTR7HTR1ASLC6A4NPC1 | |
| SCHEMBL28919881 | 0.78 | DRD2 (0.63) | DRD2HTR7HTR1ASLC6A4NPC1 | |
| SCHEMBL19287061 | 0.77 | DRD2 (0.58) | DRD2HTR7HTR1ASLC6A4NPC1 | |
| SCHEMBL3752137 | 0.77 | DRD2 (0.62) | DRD2HTR7HTR1ASLC6A4NPC1 | |
| SCHEMBL28919882 | 0.77 | DRD2 (0.62) | DRD2HTR7HTR1ASLC6A4NPC1 | |
| SCHEMBL1668218 | 0.77 | DRD2 (0.62) | DRD2HTR7HTR1ASLC6A4NPC1 | |
| SCHEMBL30093447 | 0.77 | DRD2 (0.62) | DRD2HTR7HTR1ASLC6A4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1744755-B1 | COMPOUNDS AND COMPOSITIONS AS CATHEPSIN S INHIBITORS | IRM LLC (BM) | 2012-12-05 | — | — | EP | claimed |
| US-20070232606-A1 | Compounds and Compositions as Cathepsin S Inhibitors | IRM LLC (BM) | 2007-10-04 | — | — | US | claimed |
| EP-1744755-B1 | COMPOUNDS AND COMPOSITIONS AS CATHEPSIN S INHIBITORS | IRM LLC (BM) | 2012-12-05 | — | — | EP | disclosed |
| CN-1976710-B | Compounds and compositions as cathepsin S inhibitors | IRM LLC | 2011-03-30 | — | — | CN | disclosed |
| US-20070232606-A1 | Compounds and Compositions as Cathepsin S Inhibitors | IRM LLC (BM) | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232606-A1 | Compounds and Compositions as Cathepsin S Inhibitors | CTSS, CTSB, CTSF | DRD2 4749/4885HTR7 3481/4885HTR1A 3892/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.