Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | FTO | Q9C0B1 | 10/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.45 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.45 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31580184 | 0.87 | HPGD (0.55) | HPGDTDP1ALDH1A1CYP3A4HIF1A | |
| SCHEMBL16974362 | 0.87 | HPGD (0.55) | HPGDTDP1ALDH1A1CYP3A4HIF1A | |
| SCHEMBL18685195 | 0.87 | ALDH1A1 (0.55) | HPGDTDP1ALDH1A1CYP3A4HIF1A | |
| SCHEMBL409785 | 0.86 | FTO (0.63) | HPGDTDP1ALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL18680082 | 0.85 | CYP3A4 (0.53) | HPGDTDP1ALDH1A1CYP3A4HIF1A | |
| SCHEMBL29395325 | 0.83 | HPGD (0.51) | HPGDTDP1ALDH1A1CYP3A4HIF1A | |
| SCHEMBL18270247 | 0.81 | CYP3A4 (0.48) | HPGDTDP1ALDH1A1CYP3A4HIF1A | |
| SCHEMBL19786811 | 0.81 | HPGD (0.48) | HPGDTDP1ALDH1A1CYP3A4HIF1A | |
| SCHEMBL15435547 | 0.79 | HPGD (0.60) | HPGDTDP1ALDH1A1CYP3A4HIF1A | |
| SCHEMBL13663813 | 0.79 | MAPT (0.49) | HPGDTDP1ALDH1A1CYP3A4HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180092845-A1 | ENZYME-RESPONSIVE NANOPARTICLES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-04-05 | — | — | US | disclosed |
| US-20180092845-A1 | ENZYME-RESPONSIVE NANOPARTICLES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180092845-A1 | ENZYME-RESPONSIVE NANOPARTICLES | TNNI3, TNNT2, TNNC1 | HPGD 477/4885TDP1 1064/4885ALDH1A1 540/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.