Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA2 | P47869 | 5/20 | 0.52 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | F9 | P00740 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30716670 | 0.88 | CDC7 (0.45) | GABRA2GABRB2ALDH1A1TP53HPGD | |
| SCHEMBL30452306 | 0.88 | ALDH1A1 (0.47) | GABRA2GABRB2ALDH1A1MAPTTP53 | |
| SCHEMBL22309899 | 0.86 | GABRA2 (0.54) | GABRA2GABRB2ALDH1A1GAAMAPT | |
| SCHEMBL22309820 | 0.85 | PDE4D (0.51) | GABRA2GABRB2GAAMAPTTP53 | |
| SCHEMBL29192833 | 0.84 | RAB9A (0.44) | GABRA2GABRB2ALDH1A1GAAMAPT | |
| SCHEMBL4701544 | 0.83 | ALDH1A1 (0.57) | GABRA2GABRB2ALDH1A1MAPTTP53 | |
| SCHEMBL22290179 | 0.83 | KMT2A (0.50) | ALDH1A1GAAMAPTTP53NPC1 | |
| SCHEMBL27297862 | 0.83 | PDE4B (0.44) | GABRA2ALDH1A1GAAMAPTPDE4D | |
| SCHEMBL29077940 | 0.81 | GABRA2 (0.49) | GABRA2GABRB2ALDH1A1MAPTALOX12 | |
| SCHEMBL1345334 | 0.78 | SMN1; SMN2 (0.46) | ALDH1A1GAATP53NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2022-05-24 | — | — | US | disclosed |
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2021-03-02 | — | — | US | disclosed |
| US-10894776-B2 | — | — | 2021-01-19 | — | — | US | disclosed |
| WO-2018064119-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | BLADE THERAPEUTICS, INC. (US) | 2018-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | GABRA2 2754/4885GABRB2 1579/4885ALDH1A1 4193/4885 |
| US-10894776-B2 | — | CAPNS1, CAPN9, CAPN2 | GABRA2 2840/4885GABRB2 1715/4885ALDH1A1 4421/4885 |
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | GABRA2 2754/4885GABRB2 1579/4885ALDH1A1 4193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.