Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 12/20 | 0.52 |
| ▸ | NPC1 | O15118 | 11/20 | 0.52 |
| ▸ | PKM | P14618 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | KLF5 | Q13887 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779899 | 0.77 | LMNA (0.59) | LMNACYP3A4RAB9ANPC1PKM | |
| SCHEMBL8779893 | 0.77 | LMNA (0.59) | LMNACYP3A4RAB9ANPC1PKM | |
| SCHEMBL8779898 | 0.77 | LMNA (0.59) | LMNACYP3A4RAB9ANPC1PKM | |
| Carbendazim SCHEMBL8427009 | 0.76 | LMNA (0.71) | LMNACYP3A4RAB9ANPC1PKM | |
| Carbendazim SCHEMBL29357746 | 0.76 | LMNA (0.71) | LMNACYP3A4RAB9ANPC1PKM | |
| Carbendazim SCHEMBL21051 | 0.76 | LMNA (0.71) | LMNACYP3A4RAB9ANPC1PKM | |
| SCHEMBL11989038 | 0.75 | ALDH1A1 (0.61) | LMNACYP3A4RAB9ANPC1MEN1 | |
| Carbendazim SCHEMBL74664 | 0.75 | LMNA (0.69) | LMNACYP3A4RAB9ANPC1PKM | |
| Carbendazim SCHEMBL11360169 | 0.75 | LMNA (0.69) | LMNACYP3A4RAB9ANPC1PKM | |
| Carbendazim SCHEMBL8716640 | 0.75 | LMNA (0.69) | LMNACYP3A4RAB9ANPC1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2022-05-24 | — | — | US | disclosed |
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2021-03-02 | — | — | US | disclosed |
| US-10894776-B2 | — | — | 2021-01-19 | — | — | US | disclosed |
| WO-2018064119-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | BLADE THERAPEUTICS, INC. (US) | 2018-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | LMNA 1415/4885CYP3A4 4746/4885RAB9A 2461/4885 |
| US-10894776-B2 | — | CAPNS1, CAPN9, CAPN2 | LMNA 1105/4885CYP3A4 4398/4885RAB9A 2055/4885 |
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | LMNA 1415/4885CYP3A4 4746/4885RAB9A 2461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.