Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.42 |
| ▸ | AKR1C1 | Q04828 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.39 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.39 |
| ▸ | HNF4A | P41235 | 3/20 | 0.39 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20028532 | 0.81 | HPGD (0.53) | ALDH1A1MEN1GAAHPGDKMT2A | |
| SCHEMBL4264881 | 0.75 | GAA (0.66) | ALDH1A1MEN1GAAHPGDKMT2A | |
| SCHEMBL13398620 | 0.74 | DAO (0.55) | DAOAKR1C2AKR1C1ALDH1A1MEN1 | |
| SCHEMBL13616901 | 0.74 | ALDH1A1 (0.47) | ALDH1A1MEN1GAAHPGDKMT2A | |
| SCHEMBL13398618 | 0.73 | ALDH1A1 (0.51) | DAOALDH1A1MEN1GAAHPGD | |
| SCHEMBL15700050 | 0.69 | DAO (0.42) | DAOALDH1A1HPGDPTPN1MCL1 | |
| SCHEMBL15700055 | 0.69 | HDAC3 (0.43) | DAOALDH1A1HPGDPTPN1KDM4E | |
| SCHEMBL3582859 | 0.67 | ACMSD (0.59) | AKR1C2AKR1C1PTPN1HNF4AACMSD | |
| SCHEMBL31369064 | 0.67 | ACMSD (0.59) | AKR1C2AKR1C1PTPN1HNF4AACMSD | |
| SCHEMBL30755268 | 0.67 | NPC1 (0.48) | ALDH1A1HNF4AACMSDKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2022-05-24 | — | — | US | disclosed |
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2021-03-02 | — | — | US | disclosed |
| US-10894776-B2 | — | — | 2021-01-19 | — | — | US | disclosed |
| WO-2018064119-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | BLADE THERAPEUTICS, INC. (US) | 2018-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | DAO 4284/4885AKR1C2 4507/4885AKR1C1 4510/4885 |
| US-10894776-B2 | — | CAPNS1, CAPN9, CAPN2 | DAO 4516/4885AKR1C2 4634/4885AKR1C1 4668/4885 |
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | DAO 4284/4885AKR1C2 4507/4885AKR1C1 4510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.