Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACMSD | Q8TDX5 | 3/20 | 0.59 |
| ▸ | HNF4A | P41235 | 2/20 | 0.59 |
| ▸ | DHFR | P00374 | 1/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.55 |
| ▸ | DCLRE1A | Q6PJP8 | 1/20 | 0.53 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.53 |
| ▸ | ACLY | P53396 | 7/20 | 0.51 |
| ▸ | RXRA | P19793 | 2/20 | 0.50 |
| ▸ | RXRB | P28702 | 2/20 | 0.50 |
| ▸ | LDHA | P00338 | 1/20 | 0.50 |
| ▸ | RXRG | P48443 | 1/20 | 0.50 |
| ▸ | FABP4 | P15090 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31369064 | 1.00 | ACMSD (0.59) | ACMSDHNF4ADHFRMCL1DCLRE1A | |
| SCHEMBL940864 | 0.92 | RXRB (0.54) | ACMSDHNF4ADHFRMCL1ACLY | |
| SCHEMBL31000476 | 0.92 | RXRB (0.54) | ACMSDHNF4ADHFRMCL1ACLY | |
| SCHEMBL27702500 | 0.91 | RXRA (0.49) | ACMSDHNF4ADHFRMCL1DCLRE1A | |
| SCHEMBL28566197 | 0.88 | KIF11 (0.50) | ACMSDHNF4ADHFRMCL1DCLRE1A | |
| SCHEMBL30131558 | 0.88 | IKBKB (0.56) | ACMSDHNF4ADHFRMCL1ACLY | |
| SCHEMBL27633639 | 0.87 | ACMSD (0.58) | ACMSDHNF4ADHFRMCL1DCLRE1A | |
| SCHEMBL272323 | 0.86 | RXRA (0.55) | ACLYRXRARXRB | |
| SCHEMBL8920290 | 0.85 | RXRA (0.50) | ACMSDHNF4ADHFRMCL1RXRA | |
| SCHEMBL29530817 | 0.85 | MCL1 (0.60) | ACMSDHNF4AMCL1DCLRE1BACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101068773-A | Melanin concentrating hormone antagonists | PROCTER & GAMBLE (US) | 2007-11-07 | — | — | CN | claimed |
| US-8772291-B2 | Multicyclic compounds and methods of their use | LEXICON PHARMACEUTICALS, INC. (US) | 2014-07-08 | — | — | US | disclosed |
| CN-1960969-B | Histamine H3 receptor agents, methods of preparation and therapeutic uses thereof | LILLY CO ELI | 2012-03-28 | — | — | CN | disclosed |
| US-20100081691-A1 | MULTICYCLIC COMPOUNDS AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. (US) | 2010-04-01 | — | — | US | disclosed |
| CN-101119974-A | Amide derivatives as PPAR activators | HOFFMANN LA ROCHE (CH) | 2008-02-06 | — | — | CN | disclosed |
| CN-101068773-A | Melanin concentrating hormone antagonists | PROCTER & GAMBLE (US) | 2007-11-07 | — | — | CN | disclosed |
| CN-1960969-A | Histamine H3 receptor agents, methods of preparation and therapeutic uses thereof | LILLY CO ELI (US) | 2007-05-09 | — | — | CN | disclosed |
| EP-1444225-A2 | PYRROLIDINE OXADIAZOLE- AND THIADIAZOLE OXIME DERIVATIVES BEING OXYTOCIN RECEPTOR ANTAGONISTS. | Applied Research Systems ARS Holding N.V. (AN) | 2004-08-11 | — | — | EP | disclosed |
| WO-2002102799-A2 | PYRROLIDINE OXADIAZOLE- AND THIADIAZOLE OXIME DERIVATIVES BEING OXYTOCIN RECEPTOR ANTAGONISTS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2002-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100081691-A1 | MULTICYCLIC COMPOUNDS AND METHODS OF THEIR USE | GRIN2C, CHAT, COMT | ACMSD 681/4885HNF4A 2172/4885DHFR 547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.