Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 13/20 | 0.55 |
| ▸ | PPARA | Q07869 | 9/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.53 |
| ▸ | TACR2 | P21452 | 1/20 | 0.53 |
| ▸ | DRD1 | P21728 | 1/20 | 0.53 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2002573 | 0.92 | PPARG (0.58) | PPARGPPARACYP2C9EGFRCHRM4 | |
| SCHEMBL3005150 | 0.92 | PPARG (0.57) | PPARGPPARACYP2C9EGFRCHRM4 | |
| SCHEMBL2004754 | 0.90 | PPARG (0.56) | PPARGPPARACYP2C9EGFRCHRM4 | |
| SCHEMBL2001942 | 0.90 | PPARG (0.56) | PPARGPPARACYP2C9EGFRCHRM4 | |
| SCHEMBL2008346 | 0.90 | PPARG (0.51) | PPARGPPARACYP2C9EGFRCHRM4 | |
| SCHEMBL2011874 | 0.89 | PTGDR2 (0.57) | CYP2C9ALOX5PLA2G2APLA2G1BCYP1A2 | |
| SCHEMBL4815562 | 0.88 | PLA2G2A (0.56) | PPARGPPARACYP2C9EGFRCHRM4 | |
| SCHEMBL4543998 | 0.88 | PLA2G2A (0.50) | CYP2C9ALOX5PLA2G2APLA2G1BCYP1A2 | |
| SCHEMBL2006854 | 0.86 | CYP2C9 (0.61) | PPARGPPARACYP2C9EGFRCHRM4 | |
| SCHEMBL2004551 | 0.86 | PPARG (0.64) | PPARGPPARACYP2C9EGFRCHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2610244-A1 | Indole compounds | Ironwood Pharmaceuticals, Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| US-20090264653-A1 | USEFUL INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. | 2009-10-22 | — | — | US | disclosed |
| US-20070203209-A1 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203209-A1 | Useful indole compounds | TPH2, HRH2, HRH1 | PPARG 3729/4885PPARA 3609/4885CYP2C9 2538/4885 |
| US-20090264653-A1 | USEFUL INDOLE COMPOUNDS | FAAH, FAAH2, AANAT | PPARG 3637/4885PPARA 3552/4885CYP2C9 608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.