Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAOX | Q6QHF9 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 2/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24988252 | 1.00 | PAOX (0.52) | PAOXALDH1A1ACHECES2FOLH1 | |
| SCHEMBL12592611 | 1.00 | PAOX (0.52) | PAOXALDH1A1ACHECES2FOLH1 | |
| SCHEMBL11413356 | 1.00 | PAOX (0.52) | PAOXALDH1A1ACHECES2FOLH1 | |
| SCHEMBL14141227 | 1.00 | PAOX (0.52) | PAOXALDH1A1ACHECES2FOLH1 | |
| SCHEMBL2625079 | 0.90 | — | — | |
| SCHEMBL12719928 | 0.89 | PAOX (0.43) | PAOXALDH1A1ACHECES2FOLH1 | |
| SCHEMBL12719927 | 0.89 | PAOX (0.43) | PAOXALDH1A1ACHECES2FOLH1 | |
| SCHEMBL14103859 | 0.87 | PAOX (0.40) | PAOXALDH1A1ACHECES2FOLH1 | |
| Ethylene SCHEMBL8562083 | 0.85 | ALDH1A1 (0.43) | PAOXALDH1A1ACHECES2FOLH1 | |
| SCHEMBL12719930 | 0.85 | PAOX (0.43) | PAOXALDH1A1ACHECES2FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11857603-B2 | PTH compounds with low peak-to-trough ratios | ASCENDIS PHARMA BONE DISEASES A/S (DK) | 2024-01-02 | — | — | US | disclosed |
| US-20230381284-A1 | Controlled-Release PTH Compound | ASCENDIS PHARMA BONE DISEASES AS (DK) | 2023-11-30 | — | — | US | disclosed |
| US-20230357259-A1 | BIOACTIVE CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF | SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) | 2023-11-09 | — | — | US | disclosed |
| US-11793861-B2 | PTH prodrugs | ASCENDIS PHARMA BONE DISEASES A/S (DK) | 2023-10-24 | — | — | US | disclosed |
| US-20230321198-A1 | Dosage Regimen for a Controlled-Release PTH Compound | ASCENDIS PHARMA BONE DISEASES AS (DK) | 2023-10-12 | — | — | US | disclosed |
| US-11759504-B2 | PTH compounds with low peak-to-trough ratios | ASCENDIS PHARMA BONE DISEASES A/S (DK) | 2023-09-19 | — | — | US | disclosed |
| US-20230248836-A1 | Dosage Regimen for a Controlled-Release PTH Compound | ASCENDIS PHARMA BONE DISEASES A/S (DK) | 2023-08-10 | — | — | US | disclosed |
| US-20230218722-A1 | PTH Compounds with Low Peak-To-Trough Ratios | ASCENDIS PHARMA BONE DISEASES AS (DK) | 2023-07-13 | — | — | US | disclosed |
| WO-2018060311-A1 | INCREMENTAL DOSE FINDING IN CONTROLLED-RELEASE PTH COMPOUNDS | ASCENDIS PHARMA BONE DISEASES A/S (DK) | 2018-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11793861-B2 | PTH prodrugs | PTH1R, PTMS, PHPT1 | PAOX 2385/4885ALDH1A1 2961/4885ACHE 3443/4885 |
| US-20230357259-A1 | BIOACTIVE CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF | DOCK11, PAICS, RHOA | PAOX 4546/4885ALDH1A1 1175/4885ACHE 1098/4885 |
| US-20230248836-A1 | Dosage Regimen for a Controlled-Release PTH Compound | PTH1R, CALCA, CALCR | PAOX 3422/4885ALDH1A1 4705/4885ACHE 3598/4885 |
| US-11759504-B2 | PTH compounds with low peak-to-trough ratios | PTH1R, PTMS, FGF23 | PAOX 3905/4885ALDH1A1 4537/4885ACHE 4408/4885 |
| US-20230381284-A1 | Controlled-Release PTH Compound | PTH1R, CALCA, CALCB | PAOX 3467/4885ALDH1A1 4784/4885ACHE 3907/4885 |
| US-11857603-B2 | PTH compounds with low peak-to-trough ratios | PTH1R, PTMS, FGF23 | PAOX 3905/4885ALDH1A1 4537/4885ACHE 4408/4885 |
| US-20230218722-A1 | PTH Compounds with Low Peak-To-Trough Ratios | PTH1R, PTMS, FGF23 | PAOX 3905/4885ALDH1A1 4537/4885ACHE 4408/4885 |
| US-20230321198-A1 | Dosage Regimen for a Controlled-Release PTH Compound | PTH1R, CALCB, AVPR2 | PAOX 2700/4885ALDH1A1 4797/4885ACHE 4006/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.