Sugi Predict

Sugi Predict / Compounds / SCHEMBL20030007

SCHEMBL20030007

SCHEMBL20030007

c1ccc(-c2cccc(-c3nc4oc5ccc(-c6ccc7c(c6)c6ccccc6n7-c6ccccc6)cc5c4nc3-c3cccc(-c4ccccc4)c3)c2)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 2/20 0.39
▸ KDM4E B2RXH2 1/20 0.39
▸ ATM Q13315 1/20 0.39
▸ PRKDC P78527 2/20 0.36
▸ PLA2G2A P14555 4/20 0.36
▸ PLA2G4A P47712 4/20 0.36
▸ PLA2G10 O15496 1/20 0.36
▸ TBK1 Q9UHD2 1/20 0.35
▸ TSPO P30536 1/20 0.35
▸ SMN1; SMN2 Q16637 3/20 0.34
▸ LMNA P02545 1/20 0.34
▸ PIM1 P11309 1/20 0.34
▸ CSNK2A2 P19784 1/20 0.34
▸ CSNK2B P67870 1/20 0.34
▸ PIM3 Q86V86 1/20 0.34
▸ PIM2 Q9P1W9 1/20 0.34
▸ PTGER4 P35408 1/20 0.34
▸ NPY5R Q15761 1/20 0.33
▸ PGR P06401 1/20 0.33
▸ SIRT2 Q8IXJ6 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20029869 0.94 KDM4E (0.42) L3MBTL1KDM4EATMPRKDCPLA2G2A
SCHEMBL20030008 0.94 KDM4E (0.42) L3MBTL1KDM4EATMPRKDCPLA2G2A
SCHEMBL20024786 0.91 KDM4E (0.39) L3MBTL1KDM4EATMPRKDCPLA2G2A
SCHEMBL20024233 0.91 L3MBTL1 (0.40) L3MBTL1KDM4EATMPRKDCPLA2G2A
SCHEMBL19887542 0.89 L3MBTL1 (0.39) L3MBTL1KDM4EATMPRKDCPLA2G2A
SCHEMBL21185878 0.89 KDM4E (0.39) L3MBTL1KDM4EATMPRKDCPLA2G2A
SCHEMBL21186082 0.89 KDM4E (0.39) L3MBTL1KDM4EATMPRKDCPLA2G2A
SCHEMBL20030001 0.88 KDM4E (0.35) L3MBTL1KDM4EATMPRKDCPLA2G2A
SCHEMBL23789584 0.88 PRKDC (0.32) L3MBTL1KDM4EATMPRKDC
SCHEMBL19887617 0.87 L3MBTL1 (0.38) L3MBTL1KDM4EATMPRKDCPLA2G2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12030890-B2 Compounds with diazadibenzofurane or diazadibenzothiophene structures MERCK PATENT GMBH (DE) 2024-07-09 — — US disclosed
US-12030890-B2 Compounds with diazadibenzofurane or diazadibenzothiophene structures MERCK PATENT GMBH (DE) 2024-07-09 — — US disclosed
US-11530224-B2 Compounds with diazadibenzofurane or diazadibenzothiophene structures MERCK PATENT GMBH (DE) 2022-12-20 — — US disclosed
WO-2018060307-A1 COMPOUNDS WITH DIAZADIBENZOFURANE OR DIAZADIBENZOTHIOPHENE STRUCTURES MERCK PATENT GMBH (DE) 2018-04-05 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12030890-B2 Compounds with diazadibenzofurane or diazadibenzothiophene structures DDT, ESD, DBF4 L3MBTL1 3130/4885KDM4E 1004/4885ATM 4367/4885
US-11530224-B2 Compounds with diazadibenzofurane or diazadibenzothiophene structures DDT, ESD, DBF4 L3MBTL1 3130/4885KDM4E 1004/4885ATM 4367/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.