Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | TSPO | P30536 | 1/20 | 0.34 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.34 |
| ▸ | PLA2G4A | P47712 | 3/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20029869 | 1.00 | KDM4E (0.42) | KDM4EL3MBTL1ATMNPY5RSMN1; SMN2 | |
| SCHEMBL20024786 | 0.97 | KDM4E (0.39) | KDM4EL3MBTL1ATMNPY5RSMN1; SMN2 | |
| SCHEMBL20030007 | 0.94 | L3MBTL1 (0.39) | KDM4EL3MBTL1ATMNPY5RSMN1; SMN2 | |
| SCHEMBL20024233 | 0.94 | L3MBTL1 (0.40) | KDM4EL3MBTL1ATMNPY5RSMN1; SMN2 | |
| SCHEMBL20030001 | 0.93 | KDM4E (0.35) | KDM4EL3MBTL1ATMNPY5RSMN1; SMN2 | |
| SCHEMBL20030004 | 0.90 | SMN1; SMN2 (0.34) | KDM4EL3MBTL1ATMNPY5RSMN1; SMN2 | |
| SCHEMBL20024251 | 0.89 | TBK1 (0.35) | KDM4EL3MBTL1ATMNPY5RPTGER4 | |
| SCHEMBL20967527 | 0.88 | L3MBTL1 (0.42) | KDM4EL3MBTL1ATMSMN1; SMN2LMNA | |
| SCHEMBL20030006 | 0.88 | ALOX5 (0.39) | KDM4EL3MBTL1ATMNPY5RSMN1; SMN2 | |
| SCHEMBL21185878 | 0.88 | KDM4E (0.39) | KDM4EL3MBTL1ATMNPY5RSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12030890-B2 | Compounds with diazadibenzofurane or diazadibenzothiophene structures | MERCK PATENT GMBH (DE) | 2024-07-09 | — | — | US | disclosed |
| US-12030890-B2 | Compounds with diazadibenzofurane or diazadibenzothiophene structures | MERCK PATENT GMBH (DE) | 2024-07-09 | — | — | US | disclosed |
| US-11530224-B2 | Compounds with diazadibenzofurane or diazadibenzothiophene structures | MERCK PATENT GMBH (DE) | 2022-12-20 | — | — | US | disclosed |
| EP-3519417-B1 | COMPOUNDS WITH DIAZADIBENZOFURANE OR DIAZADIBENZOTHIOPHENE STRUCTURES | MERCK PATENT GMBH (DE) | 2021-09-08 | — | — | EP | disclosed |
| WO-2018060307-A1 | COMPOUNDS WITH DIAZADIBENZOFURANE OR DIAZADIBENZOTHIOPHENE STRUCTURES | MERCK PATENT GMBH (DE) | 2018-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12030890-B2 | Compounds with diazadibenzofurane or diazadibenzothiophene structures | DDT, ESD, DBF4 | KDM4E 1004/4885L3MBTL1 3130/4885ATM 4367/4885 |
| US-11530224-B2 | Compounds with diazadibenzofurane or diazadibenzothiophene structures | DDT, ESD, DBF4 | KDM4E 1004/4885L3MBTL1 3130/4885ATM 4367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.