Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 5/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.42 |
| ▸ | IGFBP5 | P24593 | 7/20 | 0.38 |
| ▸ | IGFBP3 | P17936 | 2/20 | 0.38 |
| ▸ | ECE1 | P42892 | 1/20 | 0.37 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.35 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
| ▸ | KDM4B | O94953 | 1/20 | 0.33 |
| ▸ | KDM5C | P41229 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19268068 | 0.84 | CHRM1 (0.44) | CHRM1PDE2APDE11AIGFBP5IGFBP3 | |
| SCHEMBL20031032 | 0.83 | CHRM1 (0.53) | CHRM1PDE2APDE11A | |
| SCHEMBL20030498 | 0.73 | CHRM1 (0.49) | CHRM1PDE2APDE11A | |
| SCHEMBL20030906 | 0.72 | CHRM1 (0.42) | CHRM1PDE2APDE11AIGFBP5IGFBP3 | |
| SCHEMBL19260906 | 0.72 | CHRM1 (0.42) | CHRM1PDE2APDE11AIGFBP5IGFBP3 | |
| SCHEMBL28500321 | 0.68 | CHRM1 (0.40) | CHRM1PDE2APDE11AECE1KDM4A | |
| SCHEMBL19268090 | 0.67 | CHRM1 (0.48) | CHRM1PDE2APDE11A | |
| SCHEMBL19925995 | 0.66 | P2RX3 (0.38) | CHRM1PDE2APDE11A | |
| SCHEMBL17440047 | 0.65 | CHRM1 (0.56) | CHRM1PDE2APDE11A | |
| SCHEMBL22212646 | 0.64 | CHRM1 (0.37) | CHRM1PDE2APDE11AECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018063552-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1 | VANDERBILT UNIVERSITY (US) | 2018-04-05 | — | — | WO | disclosed |