Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 5/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22703046 | 0.84 | EGFR (0.44) | MAPK1EGFRMAOAMAOBCYP1A2 | |
| SCHEMBL20031646 | 0.81 | EGFR (0.58) | MAPK1EGFRCYP1A2ALDH1A1MEN1 | |
| SCHEMBL20031900 | 0.78 | EGFR (0.53) | MAPK1EGFRCYP1A2ALDH1A1MEN1 | |
| SCHEMBL25016883 | 0.78 | EGFR (0.42) | MAPK1EGFRMAOAMAOBSMN1; SMN2 | |
| SCHEMBL25017594 | 0.78 | PARP10 (0.43) | MAPK1EGFRALDH1A1MEN1KMT2A | |
| SCHEMBL20031910 | 0.78 | EGFR (0.44) | MAPK1EGFRMAOAMAOBALDH1A1 | |
| SCHEMBL20031647 | 0.75 | HSD11B1 (0.35) | MAPK1EGFRCYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL20031637 | 0.74 | BRD4 (0.42) | MAPK1MAOAMAOBCYP1A2CYP2C19 | |
| SCHEMBL20031875 | 0.74 | EGFR (0.51) | MAPK1EGFRCYP1A2ALDH1A1MEN1 | |
| SCHEMBL20031659 | 0.73 | MIF (0.44) | MAPK1EGFRMAOAMAOBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11578040-B2 | [5]Helicene derivatives as molecular reporters for diagnostic applications and methods of synthesis therefor | NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY (TH) | 2023-02-14 | — | — | US | disclosed |
| EP-3518746-B1 | [5]HELICENE DERIVATIVES AS MOLECULAR REPORTERS FOR DIAGNOSTIC APPLICATIONS AND METHODS OF SYNTHESIS THEREFOR | NATIONAL SCIENCE AND TECH DEVELOPMENT AGENCY (TH) | 2020-11-25 | — | — | EP | disclosed |
| WO-2018063105-A1 | [5]HELICENE DERIVATIVES AS MOLECULAR REPORTERS FOR DIAGNOSTIC APPLICATIONS AND METHODS OF SYNTHESIS THEREFOR | NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY (TH) | 2018-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11578040-B2 | [5]Helicene derivatives as molecular reporters for diagnostic applications and methods of synthesis therefor | OR51E2, HDHD5, WEE1 | MAPK1 3200/4885EGFR 381/4885MAOA 2352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.