Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.33 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | EDNRB | P24530 | 4/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2003124 | 0.94 | PLA2G2A (0.37) | LMNASMN1; SMN2MAPTALOX5APCYP3A4 | |
| SCHEMBL2003287 | 0.92 | LMNA (0.34) | LMNASMN1; SMN2MAPTCYP3A4CYP2C9 | |
| SCHEMBL2007692 | 0.91 | ALOX5AP (0.39) | LMNASMN1; SMN2MAPTALOX5APCYP3A4 | |
| SCHEMBL2002732 | 0.91 | LMNA (0.33) | LMNASMN1; SMN2MAPTALOX5APSLC26A4 | |
| SCHEMBL2001259 | 0.90 | SMN1; SMN2 (0.39) | LMNASMN1; SMN2MAPTALOX5APEDNRB | |
| SCHEMBL2001583 | 0.90 | LMNA (0.40) | LMNASMN1; SMN2MAPTPOLBEDNRB | |
| SCHEMBL2007239 | 0.89 | TP53 (0.35) | LMNASMN1; SMN2MAPTCYP3A4CYP2C9 | |
| SCHEMBL2004749 | 0.89 | L3MBTL1 (0.36) | LMNASMN1; SMN2MAPTCYP3A4CYP2C9 | |
| SCHEMBL2003311 | 0.87 | PLA2G2A (0.42) | LMNAMAPTCYP3A4CYP2C9PLA2G2A | |
| SCHEMBL2002148 | 0.87 | LMNA (0.34) | LMNASMN1; SMN2MAPTALOX5APSLC26A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |