Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | EDNRB | P24530 | 3/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2002620 | 0.93 | PLA2G2A (0.37) | LMNAMAPTALOX5APCYP3A4CYP2C9 | |
| SCHEMBL2011061 | 0.92 | ALOX5AP (0.39) | LMNASMN1; SMN2MAPTALOX5APCYP3A4 | |
| SCHEMBL2008249 | 0.91 | LMNA (0.34) | LMNASMN1; SMN2MAPTCYP3A4CYP2C9 | |
| SCHEMBL2004879 | 0.91 | ALOX5AP (0.33) | LMNASMN1; SMN2MAPTALOX5APPOLB | |
| SCHEMBL2006974 | 0.90 | LMNA (0.38) | LMNASMN1; SMN2MAPTALOX5APCYP2C9 | |
| SCHEMBL2005122 | 0.90 | S1PR1 (0.38) | LMNASMN1; SMN2MAPTALOX5APPOLB | |
| SCHEMBL2001504 | 0.89 | FAAH (0.35) | LMNASMN1; SMN2MAPTCYP3A4CYP2C9 | |
| SCHEMBL2006939 | 0.88 | L3MBTL1 (0.37) | LMNASMN1; SMN2MAPTCYP3A4CYP2C9 | |
| SCHEMBL2003234 | 0.87 | LMNA (0.35) | LMNASMN1; SMN2MAPTALOX5APPOLB | |
| SCHEMBL2008605 | 0.87 | LMNA (0.41) | LMNASMN1; SMN2MAPTPOLBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |