Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | MGLL | Q99685 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20931040 | 0.88 | MEN1 (0.31) | FAAHMGLLKMT2A | |
| SCHEMBL22957016 | 0.87 | LMNA (0.30) | — | |
| SCHEMBL23340953 | 0.86 | FAAH (0.35) | FAAHMGLLKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL22005355 | 0.84 | FAAH (0.34) | FAAHMGLLKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL19991910 | 0.84 | MGLL (0.37) | FAAHMGLLKMT2ASMN1; SMN2 | |
| SCHEMBL18501122 | 0.83 | MGLL (0.36) | FAAHMGLLKMT2ASMN1; SMN2 | |
| SCHEMBL18392597 | 0.83 | MGLL (0.36) | FAAHMGLLKMT2ASMN1; SMN2 | |
| SCHEMBL24049292 | 0.80 | FAAH (0.33) | FAAHMGLLKMT2ASMN1; SMN2 | |
| SCHEMBL18392549 | 0.79 | ALDH1A1 (0.33) | ALDH1A1MAPT | |
| SCHEMBL23153542 | 0.77 | FAAH (0.31) | FAAHMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9938323-B2 | Amatoxin derivatives and conjugates thereof as inhibitors of RNA polymerase | NOVARTIS AG (CH) | 2018-04-10 | — | — | US | disclosed |