Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2005140 | 0.95 | L3MBTL1 (0.41) | LMNAALDH1A1TSHRNPSR1MAPT | |
| SCHEMBL2012451 | 0.95 | LMNA (0.42) | LMNAALDH1A1TSHRNPSR1MAPT | |
| SCHEMBL2002347 | 0.94 | PPARG (0.37) | LMNAALDH1A1TSHRNPSR1MAPT | |
| SCHEMBL2003008 | 0.93 | PLA2G2A (0.40) | LMNAALDH1A1TSHRMAPTCYP1A2 | |
| SCHEMBL2002838 | 0.92 | LMNA (0.45) | LMNAALDH1A1TSHRMAPTALOX12 | |
| SCHEMBL2010466 | 0.91 | RET (0.38) | LMNAALDH1A1MAPTALOX12CYP1A2 | |
| SCHEMBL2002744 | 0.91 | F2RL3 (0.40) | LMNAALDH1A1TSHRNPSR1MAPT | |
| SCHEMBL2002364 | 0.90 | MAPT (0.41) | LMNAALDH1A1TSHRNPSR1MAPT | |
| SCHEMBL2003530 | 0.89 | MAPK1 (0.45) | LMNAALDH1A1TSHRNPSR1MAPT | |
| SCHEMBL2004659 | 0.88 | KDM4E (0.37) | LMNAALDH1A1TSHRNPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |