Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | PER2 | O15055 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14539264 | 0.74 | MAPT (0.44) | MEN1KMT2AMAPTRECQLKDM4E | |
| SCHEMBL18808881 | 0.71 | SMN1; SMN2 (0.36) | MAPTCYP1A2CYP2C19LMNASMN1; SMN2 | |
| SCHEMBL19262505 | 0.70 | SMN1; SMN2 (0.38) | MAPTCYP1A2CYP2C19LMNASMN1; SMN2 | |
| SCHEMBL19262427 | 0.67 | ALDH1A1 (0.36) | MAPTKDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL9859442 | 0.67 | MAPT (0.40) | MEN1KMT2AMAPTRECQLKDM4E | |
| SCHEMBL18400310 | 0.66 | PTGS2 (0.33) | MEN1KMT2AMAPTCYP1A2CYP2C19 | |
| SCHEMBL18809600 | 0.66 | LMNA (0.38) | LMNASMN1; SMN2 | |
| SCHEMBL18809216 | 0.65 | SMN1; SMN2 (0.41) | CYP1A2LMNASMN1; SMN2 | |
| SCHEMBL27551581 | 0.65 | MAPT (0.50) | MEN1KMT2AMAPTRECQLKDM4E | |
| SCHEMBL10567241 | 0.65 | CES2 (0.46) | LMNASMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2753618-B1 | HETEROCYCLIC-SUBSTITUED BENZOFURAN DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME (US) | 2018-04-11 | — | — | EP | disclosed |