Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.52 |
| ▸ | KDR | P35968 | 3/20 | 0.52 |
| ▸ | HPGDS | O60760 | 1/20 | 0.51 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | GBA1 | P04062 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3825768 | 0.84 | HPGDS (0.57) | EGFRFGFR1KDRHPGDSALKBH2 | |
| SCHEMBL4281610 | 0.81 | EGFR (0.54) | EGFRFGFR1KDRHPGDSALKBH2 | |
| SCHEMBL23719148 | 0.81 | MAPK10 (0.59) | EGFRFGFR1KDRHPGDSALKBH2 | |
| SCHEMBL4286937 | 0.81 | RAB9A (0.52) | EGFRFGFR1KDRNAMPTRAB9A | |
| SCHEMBL20048223 | 0.81 | SMN1; SMN2 (0.52) | EGFRFGFR1KDRNAMPTRAB9A | |
| SCHEMBL4293257 | 0.80 | EGFR (0.70) | EGFRFGFR1KDRHPGDSALKBH2 | |
| SCHEMBL12539322 | 0.77 | ALDH1A1 (0.50) | EGFRFGFR1KDRHPGDSALKBH2 | |
| SCHEMBL24779782 | 0.75 | RAB9A (0.54) | RAB9ASMN1; SMN2TP53NPC1 | |
| SCHEMBL6963518 | 0.74 | SCD (0.48) | EGFRFGFR1KDRHPGDSALKBH2 | |
| SCHEMBL30572150 | 0.74 | ROCK2 (0.53) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018065607-A1 | CHEMICAL SUBSTANCES WHICH INHIBIT THE ENZYMATIC ACTIVITY OF HUMAN KALLIKREIN RELATED PEPTIDASE 6 (KLK6) | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) | 2018-04-12 | — | — | WO | disclosed |
| EP-3305781-A1 | CHEMICAL SUBSTANCES WHICH INHIBIT THE ENZYMATIC ACTIVITY OF HUMAN KALLIKREIN-RELATED PEPTIDASE 6 (KLK6) | Deutsches Krebsforschungszentrum (DE) | 2018-04-11 | — | — | EP | disclosed |