Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20037200 | 0.87 | L3MBTL1 (0.48) | L3MBTL1ALDH1A1THRBPOLBSMN1; SMN2 | |
| SCHEMBL7113446 | 0.77 | CYP3A4 (0.49) | ALDH1A1SMN1; SMN2MEN1LMNAKMT2A | |
| SCHEMBL7735222 | 0.75 | TSHR (0.52) | L3MBTL1ALDH1A1POLBMAPTTSHR | |
| SCHEMBL20037048 | 0.74 | POLB (0.59) | L3MBTL1ALDH1A1POLBMEN1LMNA | |
| SCHEMBL11781967 | 0.74 | ALDH1A1 (0.61) | L3MBTL1ALDH1A1POLBSMN1; SMN2KMT2A | |
| SCHEMBL30428722 | 0.73 | BRD4 (0.61) | L3MBTL1ALDH1A1POLBSMN1; SMN2MEN1 | |
| SCHEMBL10631908 | 0.73 | BRD4 (0.61) | L3MBTL1ALDH1A1POLBSMN1; SMN2MEN1 | |
| SCHEMBL10745183 | 0.71 | POLB (0.55) | ALDH1A1POLBMEN1LMNAKMT2A | |
| SCHEMBL2880147 | 0.71 | POLB (0.52) | ALDH1A1POLBSMN1; SMN2LMNAKMT2A | |
| SCHEMBL8788960 | 0.70 | MAPT (0.55) | L3MBTL1ALDH1A1POLBMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018065607-A1 | CHEMICAL SUBSTANCES WHICH INHIBIT THE ENZYMATIC ACTIVITY OF HUMAN KALLIKREIN RELATED PEPTIDASE 6 (KLK6) | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) | 2018-04-12 | — | — | WO | disclosed |
| EP-3305781-A1 | CHEMICAL SUBSTANCES WHICH INHIBIT THE ENZYMATIC ACTIVITY OF HUMAN KALLIKREIN-RELATED PEPTIDASE 6 (KLK6) | Deutsches Krebsforschungszentrum (DE) | 2018-04-11 | — | — | EP | disclosed |