Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16792742 | 0.83 | LOXL2 (0.42) | L3MBTL1LMNAALDH1A1HPGDKDM4E | |
| SCHEMBL18181863 | 0.79 | ALDH1A1 (0.47) | L3MBTL1LMNAALDH1A1HPGDKDM4E | |
| SCHEMBL16792635 | 0.74 | UHRF1 (0.46) | L3MBTL1LMNAALDH1A1HPGDKDM4E | |
| SCHEMBL29693800 | 0.74 | ALDH1A1 (0.44) | L3MBTL1LMNAALDH1A1HPGDKDM4E | |
| SCHEMBL20040887 | 0.74 | GAA (0.50) | L3MBTL1ALDH1A1HPGDKDM4ERAB9A | |
| SCHEMBL19676352 | 0.73 | KMT2A (0.50) | ALDH1A1HPGDKDM4EHSD17B10NPC1 | |
| SCHEMBL14015136 | 0.71 | LOXL2 (0.45) | L3MBTL1ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL18331940 | 0.70 | MAP4K4 (0.42) | ALDH1A1KDM4EHSD17B10NPC1RAB9A | |
| SCHEMBL14015138 | 0.70 | HTT (0.46) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL24471268 | 0.69 | HSD17B1 (0.45) | ACACBACACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080099-B1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | HOFFMANN LA ROCHE (CH) | 2018-04-11 | — | — | EP | disclosed |