Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 5/20 | 0.59 |
| ▸ | PGR | P06401 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | BRD4 | O60885 | 2/20 | 0.45 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2004015 | 0.76 | NR3C1 (0.44) | NR3C1PGRBRD4GRIA2LMNA | |
| SCHEMBL2008107 | 0.74 | NR3C1 (1.00) | NR3C1PGRBRD4 | |
| SCHEMBL2003687 | 0.74 | CYP19A1 (0.57) | NR3C1PGRSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL2006618 | 0.74 | NR3C1 (0.51) | NR3C1PGRSMN1; SMN2BRD4MAPT | |
| SCHEMBL2009533 | 0.73 | SMN1; SMN2 (0.54) | NR3C1PGRSMN1; SMN2BRD4MAPT | |
| SCHEMBL2007374 | 0.73 | NR3C1 (0.79) | NR3C1PGRBRD4 | |
| SCHEMBL4446436 | 0.67 | LMNA (0.47) | NR3C1PGRMAPTALDH1A1KDM4E | |
| SCHEMBL2004017 | 0.67 | ALDH1A1 (0.44) | NR3C1PGRSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL27780295 | 0.65 | NR3C1 (0.54) | NR3C1PGRGRIA2ALDH1A1 | |
| SCHEMBL2002007 | 0.65 | NR3C1 (0.82) | NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960365-B2 | Compounds with medicinal effects due to interaction with the glucocorticoid receptor | N.V. ORGANON (NL) | 2011-06-14 | — | — | US | disclosed |