Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.70 |
| ▸ | TSHR | P16473 | 2/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.70 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | BLM | P54132 | 1/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | RGS12 | O14924 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2007925 | 0.92 | LMNA (0.59) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL5444206 | 0.91 | LMNA (0.62) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL2003800 | 0.91 | LMNA (0.71) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL2005008 | 0.91 | LMNA (0.59) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL5438274 | 0.90 | LMNA (0.72) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL5446385 | 0.90 | LMNA (0.70) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL5446057 | 0.90 | LMNA (0.61) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL2460905 | 0.90 | PLA2G2A (0.69) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL2004745 | 0.89 | LMNA (0.60) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL2003782 | 0.89 | PTGS2 (0.70) | LMNACYP1A2CYP3A4CYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| US-20070203209-A1 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. | 2007-08-30 | — | — | US | disclosed |
| US-20070203209-A1 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. | 2007-08-30 | — | — | US | disclosed |
| US-20070161698-A1 | Modulators of CRTH2 Activity | MICROBIA, INC. | 2007-07-12 | — | — | US | disclosed |
| US-7205329-B2 | Modulators of CRTH2 activity | MICROBIA, INC. (US) | 2007-04-17 | — | — | US | disclosed |
| WO-2007022501-A2 | USEFUL INDOLE COMPOUNDS | MICROBIA, INC. (US) | 2007-02-22 | — | — | WO | disclosed |
| US-20060135591-A1 | Modulators of CRTH2 activity | IRONWOOD PHARMACEUTICALS, INC. | 2006-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135591-A1 | Modulators of CRTH2 activity | HRH2, HRH1, MRGPRX2 | LMNA 4458/4885CYP1A2 2697/4885CYP3A4 4306/4885 |
| US-20070161698-A1 | Modulators of CRTH2 Activity | HRH2, HRH1, MRGPRX2 | LMNA 4458/4885CYP1A2 2697/4885CYP3A4 4306/4885 |
| US-20070203209-A1 | Useful indole compounds | TPH2, HRH2, HRH1 | LMNA 4592/4885CYP1A2 672/4885CYP3A4 2655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.