Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 13/20 | 0.51 |
| ▸ | GRM5 | P41594 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | METAP1 | P53582 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042814 | 0.82 | CFTR (0.52) | CFTRKMT2ALMNATSHRMAPK1 | |
| SCHEMBL20042924 | 0.78 | CNR2 (0.58) | CFTRGRM5KMT2ATSHRMEN1 | |
| SCHEMBL20042800 | 0.76 | CNR1 (0.45) | KMT2ALMNATSHRL3MBTL1MEN1 | |
| SCHEMBL20042799 | 0.76 | ALDH1A1 (0.36) | GRM5KMT2ALMNATSHRL3MBTL1 | |
| SCHEMBL20042806 | 0.73 | CNR1 (0.47) | KMT2ALMNATSHRMEN1 | |
| SCHEMBL20042763 | 0.72 | SMN1; SMN2 (0.39) | KMT2ALMNATSHRMAPK1MEN1 | |
| SCHEMBL20042764 | 0.72 | CNR1 (0.49) | KMT2ALMNATSHRMEN1 | |
| SCHEMBL20042816 | 0.70 | CNR1 (0.45) | GRM5KMT2ALMNATSHRMEN1 | |
| SCHEMBL10150244 | 0.70 | RAB9A (0.59) | CFTRKMT2AMETAP1LMNATSHR | |
| SCHEMBL20042979 | 0.70 | ALDH1A1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |