Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | TACR3 | P29371 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | GPR6 | P46095 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042880 | 0.92 | P2RX7 (0.40) | P2RX7HPGDLRRK2TACR3CNR1 | |
| SCHEMBL20042886 | 0.88 | HPGD (0.49) | P2RX7HPGDTACR3PKMGPR6 | |
| SCHEMBL20042882 | 0.87 | P2RX7 (0.41) | P2RX7TACR3CNR1CNR2GPR55 | |
| SCHEMBL20042792 | 0.87 | TACR3 (0.46) | P2RX7HPGDTACR3CNR1CNR2 | |
| SCHEMBL20042887 | 0.87 | GPR6 (0.42) | P2RX7HPGDCNR1CNR2GPR55 | |
| SCHEMBL20042752 | 0.86 | HPGD (0.47) | P2RX7HPGDTACR3CNR1CNR2 | |
| SCHEMBL20042667 | 0.85 | TACR3 (0.46) | P2RX7TACR3 | |
| SCHEMBL20042911 | 0.84 | P2RX7 (0.39) | P2RX7HPGDLRRK2TACR3CNR1 | |
| SCHEMBL20042821 | 0.83 | MEN1 (0.41) | P2RX7HPGDLRRK2MEN1KMT2A | |
| SCHEMBL20042751 | 0.82 | HSD17B10 (0.49) | P2RX7HPGDTACR3GBA1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |