Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.40 |
| ▸ | CASR | P41180 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 2/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.37 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | GPR6 | P46095 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042843 | 1.00 | GRM5 (0.40) | GRM5CASRPDE2AHCRTR1HCRTR2 | |
| SCHEMBL20042767 | 0.88 | TACR3 (0.44) | GRM5PDE2AP2RX7 | |
| SCHEMBL20042860 | 0.88 | GRM5 (0.40) | GRM5CASRHCRTR1HCRTR2SMO | |
| SCHEMBL20042932 | 0.88 | GRM5 (0.38) | GRM5CASRPDE2AHCRTR1HCRTR2 | |
| SCHEMBL20043019 | 0.88 | POLB (0.34) | GRM5P2RX7 | |
| SCHEMBL20042853 | 0.86 | GPR6 (0.34) | HCRTR1HCRTR2P2RX7GPR6 | |
| SCHEMBL20042939 | 0.86 | GRM5 (0.40) | GRM5P2RX7 | |
| SCHEMBL20042841 | 0.85 | TACR2 (0.45) | GRM5 | |
| SCHEMBL20042898 | 0.85 | TACR3 (0.45) | GRM5P2RX7 | |
| SCHEMBL20042897 | 0.85 | ALDH1A1 (0.40) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |