Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2001356 | 0.94 | FAAH (0.37) | FAAHLMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL2009971 | 0.91 | L3MBTL1 (0.37) | FAAHLMNAALDH1A1MAPTALOX12 | |
| SCHEMBL2006615 | 0.90 | FAAH (0.42) | FAAHPTGDR2PTGS1ALDH1A1MAPT | |
| SCHEMBL2004961 | 0.90 | FAAH (0.33) | FAAHPTGDR2PTGS1LMNASMN1; SMN2 | |
| SCHEMBL2002262 | 0.90 | PLA2G2A (0.37) | FAAHPTGDR2LMNATP53ALDH1A1 | |
| SCHEMBL2001270 | 0.90 | FAAH (0.41) | FAAH | |
| SCHEMBL2003432 | 0.90 | LMNA (0.41) | FAAHLMNASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL2006660 | 0.90 | CYP2C9 (0.37) | FAAHPTGDR2PTGS1LMNASMN1; SMN2 | |
| SCHEMBL2005952 | 0.89 | SLC26A4 (0.37) | FAAHLMNASMN1; SMN2TP53MAPT | |
| SCHEMBL2002612 | 0.87 | FAAH (0.35) | FAAHPTGDR2PTGS1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |