SCHEMBL20044039

SCHEMBL20044039

C=CCOc1cccc(C2CN(C)C(=O)C2C(=O)Nc2cccc(F)c2F)c1

nearest known ligand 0.36

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.36
MAPT P10636 2/20 0.36
KDM4E B2RXH2 2/20 0.36
USP2 O75604 2/20 0.36
KAT6A Q92794 1/20 0.36
GAA P10253 3/20 0.36
TP53 P04637 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.34
RXFP1 Q9HBX9 3/20 0.34
RAB9A P51151 1/20 0.33
HTT P42858 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
CFD P00746 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20044375 0.94 RAB9A (0.40) ALDH1A1MAPTKDM4EUSP2KAT6A
SCHEMBL20043888 0.90 TP53 (0.35) ALDH1A1MAPTUSP2TP53SMN1; SMN2
SCHEMBL20044408 0.90 TP53 (0.35) ALDH1A1MAPTUSP2TP53SMN1; SMN2
SCHEMBL20044064 0.89 SMN1; SMN2 (0.44) ALDH1A1MAPTKDM4ETP53SMN1; SMN2
SCHEMBL20044135 0.88 NR4A2 (0.39) USP2KAT6ATP53SMN1; SMN2RAB9A
SCHEMBL20044170 0.86 ALDH1A1 (0.43) ALDH1A1USP2GAATP53SMN1; SMN2
SCHEMBL20043989 0.86 ALDH1A1 (0.43) ALDH1A1USP2GAATP53SMN1; SMN2
SCHEMBL22621490 0.85 NPC1 (0.36) ALDH1A1MAPTUSP2KAT6ATP53
SCHEMBL20044795 0.84 TP53 (0.37) ALDH1A1MAPTTP53SMN1; SMN2MEN1
SCHEMBL20044062 0.83 SMN1; SMN2 (0.45) ALDH1A1MAPTKDM4EUSP2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2022-04-28 US disclosed
US-11180453-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2021-11-23 US disclosed
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2020-11-05 US disclosed
US-10654804-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2020-05-19 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11787765-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 ALDH1A1 1202/4885MAPT 3629/4885KDM4E 2181/4885
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ALDH1A1 1202/4885MAPT 3629/4885KDM4E 2181/4885
US-10654804-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 ALDH1A1 1202/4885MAPT 3629/4885KDM4E 2181/4885
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ALDH1A1 1182/4885MAPT 3633/4885KDM4E 2149/4885
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ALDH1A1 1202/4885MAPT 3629/4885KDM4E 2181/4885
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ALDH1A1 1202/4885MAPT 3629/4885KDM4E 2181/4885
US-11180453-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 ALDH1A1 1202/4885MAPT 3629/4885KDM4E 2181/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.