SCHEMBL20044375

SCHEMBL20044375

C=CCOc1cccc(C2CN(C)C(=O)C2C(=O)Nc2ccccc2F)c1

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 4/20 0.40
KAT6A Q92794 1/20 0.39
ALDH1A1 P00352 3/20 0.38
USP2 O75604 2/20 0.38
MAPT P10636 2/20 0.38
KMT2A Q03164 2/20 0.38
MEN1 O00255 1/20 0.38
GAA P10253 3/20 0.38
LMNA P02545 1/20 0.37
KDM4E B2RXH2 1/20 0.37
NPC1 O15118 2/20 0.36
NPSR1 Q6W5P4 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.35
KDM1A O60341 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20044039 0.94 ALDH1A1 (0.36) RAB9AKAT6AALDH1A1USP2MAPT
SCHEMBL20044062 0.89 SMN1; SMN2 (0.45) RAB9AALDH1A1USP2MAPTKMT2A
SCHEMBL20044143 0.87 RAB9A (0.40) RAB9AKAT6AALDH1A1USP2MAPT
SCHEMBL22621466 0.84 RAB9A (0.41) RAB9AALDH1A1USP2MAPTKMT2A
SCHEMBL22621507 0.84 RAB9A (0.41) RAB9AKAT6AALDH1A1USP2KMT2A
SCHEMBL20043888 0.84 TP53 (0.35) RAB9AALDH1A1USP2MAPTKMT2A
SCHEMBL20044408 0.84 TP53 (0.35) RAB9AALDH1A1USP2MAPTKMT2A
SCHEMBL20044064 0.83 SMN1; SMN2 (0.44) RAB9AALDH1A1MAPTKMT2AMEN1
SCHEMBL20048598 0.82 GAA (0.43) RAB9AKAT6AALDH1A1USP2KMT2A
SCHEMBL20048548 0.82 MEN1 (0.45) RAB9AALDH1A1USP2MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2022-04-28 US disclosed
US-11180453-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2021-11-23 US disclosed
US-10654804-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2020-05-19 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11787765-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 RAB9A 1115/4885KAT6A 3476/4885ALDH1A1 1202/4885
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 RAB9A 1115/4885KAT6A 3476/4885ALDH1A1 1202/4885
US-10654804-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 RAB9A 1115/4885KAT6A 3476/4885ALDH1A1 1202/4885
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 RAB9A 1115/4885KAT6A 3469/4885ALDH1A1 1182/4885
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 RAB9A 1115/4885KAT6A 3476/4885ALDH1A1 1202/4885
US-11180453-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 RAB9A 1115/4885KAT6A 3476/4885ALDH1A1 1202/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.