SCHEMBL20044722

SCHEMBL20044722

CN1CC(c2cc(C#N)cc(C(F)(F)F)c2)C(C(=O)Nc2cccc(F)c2F)C1=O

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAS2R14 Q9NYV8 1/20 0.36
RHOA P61586 1/20 0.35
TP53 P04637 1/20 0.34
MEN1 O00255 1/20 0.33
MAPT P10636 1/20 0.33
KMT2A Q03164 1/20 0.33
ELANE P08246 6/20 0.33
CYP2C9 P11712 2/20 0.33
TRPM8 Q7Z2W7 1/20 0.33
CYP3A4 P08684 3/20 0.33
WDR5 P61964 1/20 0.32
GPR6 P46095 1/20 0.32
USP2 O75604 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C19 P33261 1/20 0.32
ALDH1A1 P00352 1/20 0.32
EGLN1 Q9GZT9 1/20 0.32
BRAF P15056 1/20 0.32
KDR P35968 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20044728 0.89 TP53 (0.35) TP53MEN1MAPTKMT2AGPR6
SCHEMBL20044301 0.88 TP53 (0.36) TP53MEN1MAPTKMT2ATRPM8
SCHEMBL20044760 0.88 TP53 (0.36) TAS2R14TP53MEN1MAPTKMT2A
SCHEMBL20044730 0.87 P2RY1 (0.35) TP53MEN1MAPTKMT2AGPR6
SCHEMBL20048585 0.87 TP53 (0.37) TP53MEN1MAPTKMT2AGPR6
SCHEMBL30486801 0.86 GUSB (0.38) TP53MEN1KMT2A
SCHEMBL30486823 0.86 GUSB (0.38) TP53MEN1KMT2A
SCHEMBL20043889 0.85 RORC (0.38) TP53MEN1MAPTKMT2AGPR6
SCHEMBL20043960 0.85 ALDH1A1 (0.36) RHOATP53MEN1MAPTKMT2A
SCHEMBL18815248 0.84 TRPM8 (0.41) TP53MEN1MAPTKMT2ATRPM8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2022-04-28 US disclosed
US-11180453-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2021-11-23 US disclosed
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2020-11-05 US disclosed
US-10654804-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2020-05-19 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11787765-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 TAS2R14 3358/4885RHOA 874/4885TP53 1193/4885
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 TAS2R14 3358/4885RHOA 874/4885TP53 1193/4885
US-10654804-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 TAS2R14 3358/4885RHOA 874/4885TP53 1193/4885
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 TAS2R14 3393/4885RHOA 873/4885TP53 1230/4885
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 TAS2R14 3358/4885RHOA 874/4885TP53 1193/4885
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 TAS2R14 3358/4885RHOA 874/4885TP53 1193/4885
US-11180453-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 TAS2R14 3358/4885RHOA 874/4885TP53 1193/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.