SCHEMBL20044727

SCHEMBL20044727

COc1cc(Cl)cc(C2CN(C)C(=O)C2C(=O)Nc2cccc(F)c2F)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
NPC1 O15118 1/20 0.37
POLB P06746 1/20 0.37
HTT P42858 1/20 0.37
ALDH1A1 P00352 2/20 0.37
USP2 O75604 1/20 0.37
FPR1 P21462 4/20 0.36
FPR2 P25090 2/20 0.36
CRHBP P24387 1/20 0.36
CRHR2 Q13324 1/20 0.36
TP53 P04637 1/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
MDM4 O15151 1/20 0.34
MDM2 Q00987 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
HTR1D P28221 1/20 0.34
HTR1B P28222 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20044426 0.93 ALDH1A1 (0.40) RAB9ASMN1; SMN2NPC1POLBHTT
SCHEMBL20044343 0.92 TP53 (0.39) ALDH1A1TP53MEN1KMT2ALMNA
SCHEMBL20044735 0.91 ALDH1A1 (0.38) RAB9ASMN1; SMN2NPC1POLBHTT
SCHEMBL20044889 0.90 ALDH1A1 (0.38) RAB9ASMN1; SMN2NPC1POLBHTT
SCHEMBL20044080 0.89 TP53 (0.37) ALDH1A1TP53MEN1KMT2AMDM2
SCHEMBL20044170 0.89 ALDH1A1 (0.43) RAB9ASMN1; SMN2NPC1POLBHTT
SCHEMBL20043989 0.89 ALDH1A1 (0.43) RAB9ASMN1; SMN2NPC1POLBHTT
SCHEMBL20043960 0.88 ALDH1A1 (0.36) RAB9ASMN1; SMN2NPC1POLBHTT
SCHEMBL20044731 0.88 CFD (0.37) RAB9ASMN1; SMN2NPC1POLBHTT
SCHEMBL20044389 0.87 FPR2 (0.40) RAB9ASMN1; SMN2NPC1ALDH1A1USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2022-04-28 US disclosed
US-11180453-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2021-11-23 US disclosed
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2020-11-05 US disclosed
US-10654804-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2020-05-19 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11787765-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 RAB9A 1115/4885SMN1; SMN2 4288/4885NPC1 4439/4885
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 RAB9A 1115/4885SMN1; SMN2 4288/4885NPC1 4439/4885
US-10654804-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 RAB9A 1115/4885SMN1; SMN2 4288/4885NPC1 4439/4885
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 RAB9A 1115/4885SMN1; SMN2 4295/4885NPC1 4448/4885
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 RAB9A 1115/4885SMN1; SMN2 4288/4885NPC1 4439/4885
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 RAB9A 1115/4885SMN1; SMN2 4288/4885NPC1 4439/4885
US-11180453-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 RAB9A 1115/4885SMN1; SMN2 4288/4885NPC1 4439/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.